SOCO®Sodium Polyacrylate (CAS: 9003-04-7) -  Acute oral toxicity test

Sodium polyacrylate, also known as sodium 2-acrylate homopolymer [1] or sodium polyacrylate, is a widely used dispersant with a variety of applications. At room temperature, it is a colorless or light yellow viscous liquid with non-toxic and alkaline properties. Although it is insoluble in organic solvents such as ethanol and acetone, it is easily soluble in water and sodium hydroxide aqueous solution.

Key Characteristics:

Solubility: Easily soluble in water and aqueous sodium hydroxide.

Alkalinity: Non-toxic and alkaline in nature.

Compatibility: Insoluble in organic solvents but dispersible in alkaline conditions.

Molecular Weight: Ranges from 500 to 3000, allowing for effective dispersion.

Hygroscopic: Exhibits high hygroscopicity, absorbing moisture from the surroundings.

Toxicity:

Test Standard: GB/T 21603-2008

Test Sample: 20230508 batch SOCO®sodium polyacrylate 

Test Type: Acute oral toxicity test

Test Environment: Barrier system animal room. Test environment: Barrier system animal room. Professional organization standards, room temperature 21.4C-23.2C, relative humidity 51.9%~57.4%.

Test Animals: ICR mice, Experimental animals: ICR mice, purchased by unified professional institutions.

Feed Source: Feed source: the same batch of feed produced by a unified professional institution.

Number of animals/sex: 10 males,10 females (nulliparous and non-pregnant).

Sample Preparation: According to the dilution ratio requirements provided by SOCO®Sodium polyacrylate, dissolve 1g of the sample in 200ml of water, and get the diluted solution for testing after standing for 1 hour. 5.0911g sample diluted solution was poured into a 20mL volumetric flask. And diluted to the mark with pure water. The pure water was added to the calibration line. The diluent was fully shaken and poured into the reagent bottle, labeled standby. The solution was prepared and used in the same day.

Test Method: The sample was admin istered as supplied at a limit dosage as 5091.1mg/kg. The animals were fasted for 4 hours before dosing. And the animals were fasted for 3 hours after dosing. The animals were checked for mortality or signs of morbidity at least twice a day during the observation period. The body weight of each animal was recorded once a week, Gross autopsies were performed on all animals that died during the observation period and on all survivors after 14 days observation.

Caution: The obtained experimental results may exhibit non-uniqueness, meaning that variations in conditions, measurement precision, or other external factors could contribute to diverse outcomes. It is advisable to consider these potential sources of variability when interpreting and comparing results. Replication and further investigation under controlled conditions are encouraged to enhance the robustness and reliability of findings. Additionally, consult relevant literature and seek expert guidance to contextualize and validate the observed results.

【1】2-sodium acrylate homopolyme